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| | Alzheimer's drug breakthrough hailed as momentous | |  | | | | | | | | | The most common form of dementia is Alzheimer's, and people living with the condition are given medication to manage their symptoms. But the drugs they take don't alter the way the disease progresses. This could change following a treatment breakthrough, which has been hailed momentous - and historic. There is a new drug, which is the first to slow the destruction of the brain and works in the early stages of the disease. It's called lecanemab, and attacks the sticky gunge - called beta amyloid - that builds up in the brains of people with Alzheimer's.
The disease can cause memory problems, confusion and communication issues. So, the trial of the drug has provided hope. "If somebody can slow it down and eventually stop it all together that would be brilliant, it's just a horrible nasty thing," says a 78-year-old from the UK who took part in the international trial. The results show a new era of drugs is possible to treat the condition, with Prof Tara Spires-Jones stressing it's "a big deal because we've had a 100% failure rate for a long time". But lecanemab has only a small effect, and as it works in the early stages of the disease most would miss out without a revolution in detecting it. Here's the full story from our health and science correspondent James Gallagher, which includes a look at whether this drug will make a difference.
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| | England reach last 16 while World Cup hopes end for Wales | | | | | | | | | Last night saw celebrations for England and commiserations for Wales as they went head to head in the World Cup. After a goalless first half, the Three Lions soon scored not once or twice but three times against their Welsh rivals, ending their tournament hopes. Marcus Rashford hit the back of the net twice, with Phil Foden also delivering for England - here's the full match report. The 3-0 victory means they top their group and sets up a last-16 tie against Senegal on Sunday. Manager Gareth Southgate made four changes to his starting line-up, and in a post-match news conference said the big players had stepped up - read more here. But the game was a poignant personal moment for Rashford, a true exciting talent, says our chief football writer Phil McNulty. Here's why. | | | | | |
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| | The cost of train cancellations | | | | | | | | | Rail commuters are not only facing disruption from train strikes but also cancellations to services. They are the highest since records began in 2015, with the latest figures showing one in every 26 trains did not run in the year up to 12 November. It's 3.8% of all services but for many commuters, like one vet who travels from Chester to Manchester, cancellations and delays are making a straightforward journey really long and costly. "Financially it's a lot," says Jenna Blackburn. "You're coming to work to make money and you can spend more than your day's wage to get home." And she's getting home at 9pm fairly regularly. Read more on what's going on. | | | | | |
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| | | | | | | | | | | The Ukrainian government has said a scheme it created for Russian soldiers to surrender is getting up to 100 enquiries a day. The "I Want To Live" project was started in September. By calling a hotline or entering details through messenger apps, Russian troops can arrange the best way to surrender to Ukrainian forces.
Officials in Kyiv say they've had more than 3,500 contacts from invading personnel, as well as their families. There's been an apparent increase since Russian President Vladimir Putin mobilised hundreds of thousands of Russian men, and since the city of Kherson was liberated. The BBC has been given recordings from some of the calls. | | | | | | | | | | | | James Waterhouse | | Ukraine correspondent | | | | | | | | | | | |
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| | | | | | | England's 3-0 win against Wales makes the headlines this morning. The Daily Mirror, the Daily Star and the Sun dedicate their front pages to the victory, which sees the Three Lions in the last 16 of the World Cup. Photographs from the game appear in many of the other papers including in the Guardian and the Times, which also report on the results of the Alzheimer's drug trial. Fears of a turkey shortage this Christmas, the latest census data and an announcement that ambulance staff are set to go on strike are some of the other stories featuring on the front pages. Read the newspaper review in full here. | | | | | |
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| | | | | Oath Keepers Far-right militia founder guilty of US sedition | | | | | | | Royal Mail Postal workers begin fresh two-day strike | | | | | | | | | | | Twitter Covid misinformation policy ends under Musk | | | | | | |
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| | If you watch one thing today | | | | | | | | | | |
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| | If you listen to one thing today | | | | | | | | | | |
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| | If you read one thing today | | | | | | | | | | |
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| | Need something different? | | | | | | | | | When five wannabe singers were chosen to fill the gap left by the Spice Girls, the public didn't know they had picked a group who would break the pop mould. Girls Aloud made UK chart history, and now 20 years on we've looked back at their legacy, and how they really did prove everyone wrong. Take a look.
Next, to a legacy a British playwright probably didn't expect. The term gaslighting is used frequently these days, so much so it has been chosen as the word of the year by one dictionary publisher. But did you know its origin derives from Patrick Hamilton's 1938 play called Gas Light? Find out more here.
And finally, they say a picture is worth a thousand words but does that also apply to moving images? A starling murmuration has been captured on camera above a nature reserve in Somerset, and some say it's amazing. Watch the video to decide for yourself. | | | | | |
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| | On this day | | | | | | | 1995 Bill Clinton becomes the first serving US president to visit Northern Ireland. | | | | | | | | |
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| | | Let us know what you think of this newsletter by emailing bbcnewsdaily@bbc.co.uk. If you’d like to recommend it to a friend, forward this email. New subscribers can sign up here. | | | | | |
